Purinergic receptor immunoreactivity in the rostral ventromedial medulla
نویسندگان
چکیده
منابع مشابه
Administration of orexin receptor 1 antagonist into the rostral ventromedial medulla increased swim stress-induced antinociception in rat
Objective(s): Intracerebroventricular injection of orexin-A (hypocretin-1) antagonist has been shown to inhibit stress-induced analgesia. However the locations of central sites that may mediate these effects have not been totally demonstrated. This study was performed to investigate the role of rostral ventromedial medulla (RVM) orexin receptor 1 in stress-induced analgesia (SIA). Materials and...
متن کاملKappa opioid receptor (KOR) and GAD67 immunoreactivity are found in OFF and NEUTRAL cells in the rostral ventromedial medulla.
This study combines functional and anatomical characterization of neurons in the rostral ventromedial medulla (RVM) to show distinct neurochemical phenotypes between functional classes of neurons. The RVM contains three functional classes of neurons: off cells show a pause in spontaneous activity prior to a nociceptive withdrawal reflex; on cell activity increases prior to a nociceptive reflex;...
متن کاملPermanent lesion in rostral ventromedial medulla potentiates swim stress-induced analgesia in formalin test
Objective(s): There are many reports about the role of rostral ventromedial medulla (RVM) in modulating stress-induced analgesia (SIA). In the previous study we demonstrated that temporal inactivation of RVM by lidocaine potentiated stress-induced analgesia. In this study, we investigated the effect of permanent lesion of the RVM on SIA by using formalin test as a model of acute inflammatory pa...
متن کاملadministration of orexin receptor 1 antagonist into the rostral ventromedial medulla increased swim stress-induced antinociception in rat
objective(s): intracerebroventricular injection of orexin-a (hypocretin-1) antagonist has been shown to inhibit stress-induced analgesia. however the locations of central sites that may mediate these effects have not been totally demonstrated. this study was performed to investigate the role of rostral ventromedial medulla (rvm) orexin receptor 1 in stress-induced analgesia (sia). materials and...
متن کاملRostral ventromedial medulla neurons that project to the spinal cord express multiple opioid receptor phenotypes.
The rostral ventromedial medulla (RVM) forms part of a descending pathway that modulates nociceptive neurotransmission at the level of the spinal cord dorsal horn. However, the involvement of descending RVM systems in opioid analgesia are a matter of some debate. In the present study, patch-clamp recordings of RVM neurons were made from rats that had received retrograde tracer injections into t...
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ژورنال
عنوان ژورنال: Neuroscience
سال: 2009
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2008.08.044